HIV/AIDS Causes Signs & Symptoms




CD4 Cell CategoriesClinical Categories
Abbreviations: PGL = persistent generalized lymphadenopathy
A Asymptomatic, Acute HIV, or PGLB* Symptomatic Conditions, not A or CC# AIDS-Indicator Conditions
(1) ≥500 cells/µLA1B1C1
(2) 200-499 cells/µLA2B2C2
(3) <200 cells/µLA3B3C3

* CDC CLASSIFICATION SYSTEM FOR HIV The Category B Symptomatic Conditions Category B symptomatic conditions are defined as symptomatic conditions occurring in an HIV-infected adolescent or adult that meets at least one of the following criteria:

They are attributed to HIV infection or indicate a defect in cell-mediated immunity.

They are considered to have a clinical course or management that is complicated by HIV infection. Examples include, but are not limited to, the following:

  • Bacillary angiomatosis
  • Oropharyngeal candidiasis (thrush)
  • Vulvovaginal candidiasis, persistent or resistant
  • Pelvic inflammatory disease (PID)
  • Cervical dysplasia (moderate or severe)/cervical carcinoma in situ
  • Hairy leukoplakia, oral
  • Herpes zoster (shingles), involving two or more episodes or at least one dermatome
  • Idiopathic thrombocytopenic purpura
  • Constitutional symptoms, such as fever (>38.5ºC) or diarrhea lasting >1 month
  • Peripheral neuropathy
# Category C AIDS-Indicator Conditions
  • Bacterial pneumonia, recurrent (two or more episodes in 12 months)
  • Candidiasis of the bronchi, trachea, or lungs
  • Candidiasis, esophageal
  • Cervical carcinoma, invasive, confirmed by biopsy
  • Coccidioidomycosis, disseminated or extrapulmonary
  • Cryptococcosis, extrapulmonary
  • Cryptosporidiosis, chronic intestinal (>1 month in duration)
  • Cytomegalovirus disease (other than liver, spleen, or nodes)
  • Encephalopathy, HIV-related
  • Herpes simplex: chronic ulcers (>1 month in duration), or bronchitis, pneumonitis, or esophagitis
  • Histoplasmosis, disseminated or extrapulmonary
  • Mycobacterium tuberculosis, pulmonary or extrapulmonary
  • Isosporiasis, chronic intestinal (>1-month duration)
  • Kaposi sarcoma
  • Lymphoma, Burkitt, immunoblastic, or primary central nervous system
  • Mycobacterium avium complex (MAC) or Mycobacterium kansasii, disseminated or extrapulmonary
  • Mycobacterium tuberculosis, pulmonary or extrapulmonary
  • Pneumocystis jiroveci (formerly carinii) pneumonia (PCP)
  • Progressive multifocal leukoencephalopathy (PML)
  • Salmonella septicemia, recurrent (nontyphoid)
  • Toxoplasmosis of brain
  • Mycobacterium, other species or unidentified species, disseminated or extrapulmonary
  • Wasting syndrome caused by HIV (involuntary weight loss >10% of baseline body weight) associated with either chronic diarrhea (two or more loose stools per day for ≥1 month) or chronic weakness and documented fever for ≥1 month



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